Mutagenicity of Smoke Flavorings

Effects of Flue-curing on Cigarette Smoke Condensates Mutagenicity*

Flue-curing is a post harvest conditioning process which strongly affects the tobacco leaf chemistry, and consequently the chemical properties of tobacco smoke. Several studies identified the major changes in tobacco chemistry occurring during flue-curing. It is not known how flue-curing contributes to changes in bioactivity of cigarette smoke condensate (CSC). In this study, tobacco leaves col...

Candy flavorings in tobacco.

In vitro tests with fresh cigarette smoke - Effects of charcoal filters on whole smoke and vapour phase mutagenicity and genotoxicity

In vitro analysis of fresh smoke is an important part of cigarette testing because the exposure methods employed may reflect human smoke exposure. Whole smoke is a dynamic system and has to be handled accordingly. In a few seconds smoke changes its properties. Therefore, the period of time until the smoke is in contact with cells has to be kept as short as possible. The same preconditions need ...

Comparative evaluation of the mutagenicity and genotoxicity of smoke condensate derived from Korean cigarettes

OBJECTIVES Cigarette smoking is associated with carcinogenesis owing to the mutagenic and genotoxic effects of cigarette smoke. The aim of this study was to evaluate the mutagenic and genotoxic effects of Korean cigarettes using in vitro assays. METHODS We selected 2 types of cigarettes (TL and TW) as benchmark Korean cigarettes for this study, because they represent the greatest level of nic...

Mutagenicity of 11 cigarette smoke condensates in two versions of the mouse lymphoma assay.

Cigarette smoke condensate (CSC) is genotoxic in nearly all assays in which it has been tested. In this study, we investigated the mutagenicity of 11 CSCs using the microwell and soft-agar versions of the mouse lymphoma assay (MLA). These CSCs were prepared from commercial or experimental cigarettes, 10 of them were produced using International Organisation for Standardisation (ISO) conditions ...